https://www.forbes.com/2009/08/03/day-trips-driving-lifestyle-travel-road-trips.html

Check this article from Forbes:

Origin: Charlotte, N.C.

Destination: Asheville, N.C.

Located 130 miles from Charlotte in Asheville is the Biltmore House, a 250-room country retreat built between 1888 and 1895 by George Washington Vanderbilt II. Great for a day's visit or weekend getaway, the estate includes a winery, acres of beautiful gardens, and various inns and cottages. Summer evening concerts will be held on the South Terrace until the end of this month.

An alternative getaway is to Chapel Hill, rock capital of the Carolinas, 142 miles from Charlotte.